Emily Clark

Profile

Emily Clark studied an MEng in Mechanical Engineering at the University of Leeds, specialising in Medical Engineering and Biomechanics. She was then accepted onto a Centre for Doctoral Training MSc and Ph.D. programme again at the University of Leeds. This programme aimed to take physical scientists and engineers and train them to tackle problems in medical science.

Her Ph.D. work focussed on the cardiovascular system, and abdominal aortic aneurysms in particular. The work was spread across the Institute of Medical and Biological Engineering and Leeds Institute for Cardiovascular and Metabolic Medicine. The aims was to develop a porcine ex vivo model of abdominal aortic aneurysm using a bioreactor and to investigate the role of the smooth muscle cells and arterial biomechanics in this disease. The outcome of this was a fully characterised disease model and a much better understanding of cellular and molecular biology.

Research interests

Her research interests are primarily in the field of medical and biological engineering, and investigating the effects of engineering processes on cardiovascular cells. Her current research involves exploring the effects of products of biotribocorrosion on vascular cells in the Institute of Functional Surfaces and their potential role of in-stent restenosis (ISR), which is currently unknown. ISR is the leading cause of vascular stent failure. The project will last two years and aims to simulate physiological biotribocorrosion products and investigate their effects on human smooth muscle and endothelial cells. The behaviour of the cells will be characterised with the potential for uncovering this pathological pathway. This may uncover targets for therapeutics to prevent restenosis in stents.

http://www.nhs.uk/conditions/coronary-angioplasty/pages/treatment.aspx

 

 

 

Qualifications

  • MEng Mechanical Engineering
  • MSc Medical and Biological Engineering
  • PhD Medical and Biological Engineering

Professional memberships

  • European Vascular Biology Organisation (EVBO)
  • British Society for Cardiovascular Research (BSCR)

Research groups and institutes

  • Institute of Functional Surfaces

Publications:

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